Expression of CXCR4 in tumor and bone marrow of gastric cancer patients: association with hypoxia-regulated indices, disseminated tumor cells and survival

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dc.contributor.author Osinsky D.
dc.contributor.author Kovelskaya A.
dc.contributor.author Bubnovskaya L
dc.contributor.author Ganusevich I.
dc.contributor.author Gumenyuk L.
dc.contributor.author Merentsev S.
dc.contributor.author Osinsky S.
dc.contributor.author Mamontova L.
dc.date.accessioned 2023-06-29T12:27:09Z
dc.date.available 2023-06-29T12:27:09Z
dc.date.issued 2014
dc.identifier.udk https://reposit.uni-sport.edu.ua/handle/787878787/4606
dc.description Expression of CXCR4 in tumor and bone marrow of gastric cancer patients: association with hypoxia-regulated indices, disseminated tumor cells and survival / D. Osinsky et all. Annals of Oncology. 2014. uk_UA
dc.description.abstract Aim: CXCR4 expression is associated with metastasis and poor outcome of various cancers but its role in gastric cancer (GC) is still unclear. This study was aimed to analyze the association of CXCR4 expression in GC and bone marrow (BM) with clinical outcome. Methods: 65 resected tumor specimens were studied. immunohistochemistry, NMR-spectroscopy, and zymography were used. Disseminated tumors cells (DTCs) in BM was detected by immunocytochemistry. All patients were thoroughly informed about the study. Statistical analyses were done using NCSS2000/PASS2000 and Prism (version 4.03) software packages. Results: CXCR4 protein was expressed in 78.5% of GC specimens. It was correlated with level of tumor hypoxia (assessed by PME/Pi ratio; r = 0.492, p < 0.05), VEGF expression (r = 0.337, p < 0.01) and gelatinases activity (r = 0.33; p < 0.05). CXCR4+ cells in GC was detected in 80% of patients with DTC in BM. Overall survival (OS) of patients with CXCR4+-tumors was poorer than that of patients with CXCR4−-tumors (p < 0.037). The CXCR4+ cells in BM was found in 46% of all patients, and in 56% of patients with DTC. It was also detected that CXCR4+ cells in BM in patients with M0 category was detected in 63% of patients with DTC. CXCR4 expression in BM was not associated with OS. It was evaluated that in all patients with CXCR+ tumors risk of unfavorable outcome increased by more a factor of 2.82 (HR = 2.82; 95%CI 1.162–6.832; p < 0.05). CXCR4 expression in BM was positively associated with DTC, especially in patients with M0 category. It was observed that in patients both with M0 category and CXCR4+ BM risk of unfavorable outcome increased by a factor of 3.4 (HR = 3.4; 95%CI 1.156–12.054; p < 0.03). Conclusions: CXCR4 expression in tumor was positively correlated with hypoxia and VEGF expression in tumor and OS. CXCR4 expression in BM is associated with DTC. uk_UA
dc.language.iso en uk_UA
dc.publisher Annals of Oncology uk_UA
dc.subject CXCR4 uk_UA
dc.subject gastric cancer uk_UA
dc.subject bone marrow (BM) uk_UA
dc.subject оverall survival uk_UA
dc.subject нypoxia uk_UA
dc.title Expression of CXCR4 in tumor and bone marrow of gastric cancer patients: association with hypoxia-regulated indices, disseminated tumor cells and survival uk_UA
dc.type Article uk_UA


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