CXCR4 Expression in Gastric Cancer and Bone Marrow: Association with Hypoxia-Regulated Indices, Disseminated Tumor Cells, and Patients Survival.

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dc.contributor.author Osinsky, D
dc.contributor.author Kovelskaya, A
dc.contributor.author Bubnovskaya, L
dc.contributor.author Ganusevich, I
dc.contributor.author Gumenyuk, L
dc.contributor.author Merentsev, S
dc.contributor.author Osinsky, S
dc.contributor.author Mamontova, L
dc.date.accessioned 2023-05-09T10:34:06Z
dc.date.available 2023-05-09T10:34:06Z
dc.date.issued 2015
dc.identifier.udk https://reposit.uni-sport.edu.ua/handle/787878787/4515
dc.description CXCR4 Expression in Gastric Cancer and Bone Marrow: Association with Hypoxia-Regulated Indices, Disseminated Tumor Cells, and Patients Survival / Dmitry Osinsky et al. // Journal of Cancer Research. - 2015. - Vol. 9. - P. 1-8. - DOI: 10.1155/2015/980214. uk_UA
dc.description.abstract Aim:The analysis of the association of CXCR4 expression in gastric cancer (GC) and bone marrow (BM) with clinical characteristics. Patients and Methods: 65 patients with GC were investigated. Immunohistochemistry, immunocytochemistry, NMR-spectroscopy, and zymography were used. Results: CXCR4 was expressed in 78.5% of GC specimens and correlated with tumor hypoxia (p < 0.05), VEGF expression (p < 0.01), and gelatinases activity (p < 0.05). CXCR4-positive cells in GC were detected in 80% of patients with disseminated tumor cells (DTCs). Overall survival (OS) of patients with CXCR4-positive tumors was poorer than that of patients with CXCR4-negative tumors (p = 0.037). The CXCR4-positive cells in BMwere found in 46% of all patients and in 56% of patients with DTCs. CXCR4 expression in BMwas not associated with OS. Risk of unfavourable outcome is increased in patients with CXCR4-positive tumors (p < 0.05). CXCR4 expression in BM was positively associated with DTCs, especially in patients with M0 category. Risk of unfavourable outcome is increased in patients with M0 category and with both CXCR4-positive BM and DTCs (p = 0.03). Conclusions: CXCR4 expression in tumor was positively correlated with hypoxia level and VEGF expression in tumor as well as OS. CXCR4 expression in BM is associated with DTCs. uk_UA
dc.language.iso en uk_UA
dc.publisher Journal of Cancer Research uk_UA
dc.subject CXCR4 uk_UA
dc.subject gastric cancer (GC) uk_UA
dc.subject bone marrow (BM) uk_UA
dc.subject Overall survival uk_UA
dc.subject disseminated tumor cells (DTCs) uk_UA
dc.subject Hypoxia tumor uk_UA
dc.title CXCR4 Expression in Gastric Cancer and Bone Marrow: Association with Hypoxia-Regulated Indices, Disseminated Tumor Cells, and Patients Survival. uk_UA
dc.type Article uk_UA


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