CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome

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dc.contributor.author Osinsky S.
dc.contributor.author Kovelskaya A.
dc.contributor.author Bubnovskaya L.
dc.contributor.author Osinsky D.
dc.contributor.author Merentsev S.
dc.date.accessioned 2019-08-08T12:10:12Z
dc.date.available 2019-08-08T12:10:12Z
dc.date.issued 2015
dc.identifier.udk http://reposit.uni-sport.edu.ua/handle/787878787/1711
dc.description CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome / S. Osinsky, S. Merentsev, A. Kovelskaya, L. Bubnovskaya, D. Osinsky // Exp Oncol. – 2015. – V. 37, № 1. – Р. 48-52. uk_UA
dc.description.abstract Aim: To evaluate the association between the presence of CD8 and CD45RO T lymphocytes in bone marrow (BM), disseminated tumor cells (DTCs), tumor hypoxia and their impact on disease outcome. Material and methods: 91 naïve gastric cancer (GC) patients were enrolled into the study. DTCs, CD8- and CD45RO-positive T lymphocytes in BM were detected using immunocytochemistry. All patients were thoroughly informed about the study that was approved by the local ethics committee. Statistical analyses were done using NCSS2000/PASS2000 and Prism, version 4.03 software packages. Results: It was detected that 80.5 and 81.3% of patients had CD8- and CD45RO-positive T cells in BM, respectively. When DTCs were detected in BM, the number of patients with CD8-and CD45RO-positive T cells in BM were 86.1 and 84.4%, respectively. It was also determined that the number of patients with DTCs in BM with categories M0 and M1 and with CD8- and CD45RO-positive T cells in BM were 86.2 and 85.7%, 85.7 and 80.0%, respectively. The association between DTCs in BM and presence of CD8 and CD45RO T cells lymphocytes in BM was not found. At the same time it was shown the association between presence of CD8 and CD45RO T lymphocytes and survival. The presence of CD8- and CD45RO-positive T cells in BM were accompanied with significantly longer overall survival of patients compared to that of patients without CD8- and CD45RO-positive T cells in BM. Conclusion: Patients with the presence of CD8- and CD45RO-positive T cells in BM demonstrated better survival of GC patients than those with the absence of these cells in BM. It may be suggested that tumor cells in BM are controlled in a dormant state by T cells in BM, in particular by CD8-positive T cells. uk_UA
dc.language.iso en uk_UA
dc.publisher Experimental Оncology uk_UA
dc.subject CD8 T lymphocytes uk_UA
dc.subject CD45RO T lymphocytes uk_UA
dc.subject bone marrow (BM) uk_UA
dc.subject disseminated tumor cells (DTCs) uk_UA
dc.subject Hypoxia tumor uk_UA
dc.subject survival uk_UA
dc.title CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome uk_UA
dc.type Article uk_UA


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