Selectivity of effects of redox-active cobalt (III) complexes on tumor tissue

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dc.contributor.author Osinsky S.
dc.contributor.author Levitin I.
dc.contributor.author Sigan A.
dc.contributor.author Bubnovskaya L.
dc.contributor.author Ganusevich I.
dc.contributor.author Kovelskaya A.
dc.contributor.author Valkovskaya N.
dc.contributor.author Campanella L.
dc.contributor.author Wardman P.
dc.date.accessioned 2019-07-12T10:45:56Z
dc.date.available 2019-07-12T10:45:56Z
dc.date.issued 2004
dc.identifier.udk http://reposit.uni-sport.edu.ua/handle/787878787/1702
dc.description Selectivity of effects of redox-active cobalt (III) complexes on tumor tissue / S. Osinsky, I. Levitin, A. Sigan, L. Bubnovskaya // Experimental Оncology. - 2004. uk_UA
dc.description.abstract Aim: To estimate the selectivity of action of cobalt complexes on tumor tissue. Materials and Methods: Cobalt (III) complexes containing both the tetradentate Schiff-base ligand derived from acetylacetone and ethylenediamine, and compounds of the vitamin PP series or their synthetic analogs, viz. nicotinamide, isonicotinamide or nicotinic acid, as extra (axial) ligands, were tested in vivo on transplanted mice tumors, namely Lewis lung carcinoma (3LL), melanoma B16, and mammary adenocarcinoma Ca755. Concentrations of malondialdehyde in tissue extracts were measured by standard biochemical methods. The rate of DNA unwinding was used to detect DNA damage in tumor cells. Level of tumor hypoxia as well as bioenergetic status were estimated using 31P NMR spectroscopy in perchloric acid extracts of tissue. Results: A significant and selective increase of … uk_UA
dc.language.iso en uk_UA
dc.publisher Experimental Оncology uk_UA
dc.subject Cobalt complexes uk_UA
dc.subject Redox uk_UA
dc.subject tumor hypoxia uk_UA
dc.subject selectivity uk_UA
dc.subject reactive oxygen species uk_UA
dc.title Selectivity of effects of redox-active cobalt (III) complexes on tumor tissue uk_UA
dc.type Article uk_UA


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