Detection of tumor response to Co(III) and Fe(III) complexes by 31P-Nuclear Magnetic Resonance Spectroscopy

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dc.contributor.author Bubnovskaya L.
dc.contributor.author Mikhailenko V.
dc.contributor.author Kondrichin I.
dc.contributor.author Osinsky S.
dc.contributor.author Kovelskaya A.
dc.contributor.author Sigan A.
dc.contributor.author Levitin I.
dc.date.accessioned 2018-05-30T11:29:53Z
dc.date.available 2018-05-30T11:29:53Z
dc.date.issued 2002
dc.identifier.udk http://reposit.uni-sport.edu.ua/handle/787878787/1403
dc.description Detection of tumor response to Co(III) and Fe(III) complexes by 31P-Nuclear Magnetic Resonance Spectroscopy / Bubnovskaya L., Mikhailenko V., Kondrichin I., Osinsky S. [et al.] // Экспериментальная онкология. - 2002. - № 24. - С. 128-134. uk_UA
dc.description.abstract A comparative analysis of the effects of several Co (III) and one Fe (III) complexes, as well as that of CoCl2 on the “bioenergetic status” as well as tumor hypoxia in Guerin carcinoma has been carried out using 31P NMR. Existence of the inverse correlation between the changes in the “bioenergetic status” of tumor tissue after complexes administration and their antitumor efficacy has been shown in experiments in vivo. The hypoxia levels in tumor that were registered under these conditions have been corresponded to antitumor activities of the complexes. Complexes were shown to exhibit a time-dependent influence on tissue energy metabolism. It has been also demonstrated that 31P NMR spectroscopy may be used to characterize the physiological state of tissues and applied on optimization of drug design and prediction of antitumor efficacy of newly synthesized substances. uk_UA
dc.language.iso en uk_UA
dc.publisher Экспериментальная онкология uk_UA
dc.subject Co(III) complexes uk_UA
dc.subject Fe(III) complexes uk_UA
dc.subject 31P-NMR-spectroscopy uk_UA
dc.subject Guerin carcinoma uk_UA
dc.title Detection of tumor response to Co(III) and Fe(III) complexes by 31P-Nuclear Magnetic Resonance Spectroscopy uk_UA
dc.type Article uk_UA


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