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Перегляд Науково-дослідний центр Інституту по Автору "Kovelskaya A."

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Bioenergetic status and hypoxia in Lewis lung carcinoma assassed by 31P NMR spectroscopy: correlation with tumor progression.

Bubnovskaya L.; Mikhailenko V.; Kovelskaya A.; Osinsky S. (Experimental Оncology, 2007)

Aim: Тo evaluate the hypoxia level and some indices of Lewis lung carcinoma energy metabolism by means of 31Р NMR spectroscopy in perchloric acid (PCA) tissue extracts during growth of primary tumor and metastasis. Мaterials ...
CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome

Osinsky S.; Kovelskaya A.; Bubnovskaya L.; Osinsky D.; Merentsev S. (Experimental Оncology, 2015)

Aim: To evaluate the association between the presence of CD8 and CD45RO T lymphocytes in bone marrow (BM), disseminated tumor cells (DTCs), tumor hypoxia and their impact on disease outcome. Material and methods: 91 naïve ...
Detection of tumor response to Co(III) and Fe(III) complexes by 31P-Nuclear Magnetic Resonance Spectroscopy

Bubnovskaya L.; Mikhailenko V.; Kondrichin I.; Osinsky S.; Kovelskaya A.; Sigan A.; Levitin I. (Экспериментальная онкология, 2002)

A comparative analysis of the effects of several Co (III) and one Fe (III) complexes, as well as that of CoCl2 on the “bioenergetic status” as well as tumor hypoxia in Guerin carcinoma has been carried out using 31P NMR. ...
Disseminated tumor cells in bone marrow of gastric cancer patients: correlation with tumor hypoxia and clinical relevance

Kovelskaya A.; Bubnovskaya L.; Gumenyuk L.; Mamontova L.; Mikhailenko V.; Osinsky D.; Merentsev S.; Osinsky S. (Journal of Oncology, 2014)

The evaluation of the clinical relevance of disseminated tumor cells (DTCs) in bone marrow (BM) of patients with gastric cancer (GC) and their association with primary tumor hypoxia. Patients and Methods. 89 resected ...
Expression of CXCR4 in tumor and bone marrow of gastric cancer patients: association with hypoxia-regulated indices, disseminated tumor cells and survival

Osinsky D.; Kovelskaya A.; Bubnovskaya L; Ganusevich I.; Gumenyuk L.; Merentsev S.; Osinsky S.; Mamontova L. (Annals of Oncology, 2014)

Aim: CXCR4 expression is associated with metastasis and poor outcome of various cancers but its role in gastric cancer (GC) is still unclear. This study was aimed to analyze the association of CXCR4 expression in GC and ...
Hypoxia level and matrix metalloproteinases-2 and -9 activity in Lewis lung carcinoma: correlation with metastasis

Osinsky S.; Ganusevich I.; Bubnovskaya L.; Valkovskaya N.; Kovelskaya A.; Sergienko T.; Zimina S. (Experimental Оncology, 2005)

To investigate the relationship between tumor hypoxia in vivo, activiti of matrix metalloproteinases (MMPs), and metastatic potential of tumor.
Hypoxia-regulated proteins (HRPs) and matrix metalloproteinases (MMPs) in gastric cancer: impact on malignant progression

Osinsky S.; Bubnovskaya L.; Ganusevich I.; Kovelskaya A.; Yurchenko O.; Gumenyuk L.; Chorny A. (Clinical and Translational Oncology, 2004)

To evaluate the interrelationship between hypoxia level, expression of HRPs and activity of MMPs in tumor tissue and assess the impact of these parameters on malignant progression.
Nanohyperthermia of malignant tumors. I. Lanthanum-strontium manganite magnetic fluid as potential inducer of tumor hyperthermia

Solopan S.; Belous A.; Yelenich A.; Kovelskaya A.; Chekhun V.; Podoltsev A.; Kondratenko I.; Osinsky S. (Experimental Оncology, 2011)

To synthesize magnetic particles of lanthanum-strontium manganite, prepare the magnetic fluid (MF), evaluate the generation of heat by particles and determine their common toxiсity. Methods: Nanoparticles based on the solid ...
Nanohyperthermia of malignant tumors. II. In vivo tumor heating with manganese perovskite nanoparticles.

Kovelskaya A.; Bubnovskaya L.; Belous A.; Solopan A.; Podoltsev A.; Kondratenko I.; Sergienko T.; Osinsky S. (Экспериментальная онкология, 2012)

To evaluate the ability of manganese perovskite nanoparticles (lanthanum-strontium manganite) to heat the tumor tissue in vivo under action of external alternating magnetic field. Materials and Methods: The magnetic fluid ...
Redox-active cobalt complexes as selective anticancer agents: mechanisms of activity

Osinsky S.; Bubnovskaya L.; Levitin I.; Sigan A.; Ganusevich I.; Kovelskaya A.; Valkovskaya N.; Campanella L.; Wardman P. (British Journal of Cancer, 2003)

To study mechanisms of biological activity of novel cobaltcomplexes (CoC) displaing anticancer effect.
Selectivity of effects of redox-active cobalt (III) complexes on tumor tissue

Osinsky S.; Levitin I.; Sigan A.; Bubnovskaya L.; Ganusevich I.; Kovelskaya A.; Valkovskaya N.; Campanella L.; Wardman P. (Experimental Оncology, 2004)

Aim: To estimate the selectivity of action of cobalt complexes on tumor tissue. Materials and Methods: Cobalt (III) complexes containing both the tetradentate Schiff-base ligand derived from acetylacetone and ethylenediamine, ...

Перегляд Науково-дослідний центр Інституту по Автору "Kovelskaya A."

Перегляд Науково-дослідний центр Інституту по Автору "Kovelskaya A."

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