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Hypoxia, tumour-associated macrophages, microvessel density, VEGF and matrix metalloproteinases in human gastric cancer: interaction and impact on survival.

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dc.contributor.author Kovelskaya A. (Ковельська А.)
dc.contributor.author Bubnovskaya L. (Бубновська Л.)
dc.contributor.author Ganusevich I. (Ганушевич І.)
dc.contributor.author Osinsky S. (Осінський С.)
dc.contributor.author Gumenyuk L. (Гуменюк Л.)
dc.contributor.author Merentsev S. (Меренцев С.)
dc.contributor.author Olijnichenko G.
dc.date.accessioned 2020-07-31T10:52:48Z
dc.date.available 2020-07-31T10:52:48Z
dc.date.issued 2011
dc.identifier.uri http://reposit.uni-sport.edu.ua/handle/787878787/2875
dc.description Hypoxia, tumour-associated macrophages, microvessel density, VEGF and matrix metalloproteinases in human gastric cancer: interaction and impact on survival / A. Kovelskaya, L. Bubnovskaya. I. Ganusevich, S. Osinsky, L. Gumenyuk, S. Merentsev, G. Olijnichenko // Clin Transl Oncol. - 2011. - №13. - Р. 133-138. uk_UA
dc.description.abstract Introduction: Hypoxia is a key feature of the microenvironment of cancer cells actively participating in tumour progression. Our study was aimed to evaluate the impact of hypoxia and hypoxia-associated factors on tumour progression and survival of patients with gastric cancer. Material and methods: One hundred and five resected specimens were used. The level of tumour hypoxia was evaluated using 31P NMR spectroscopy, CD68 (tumour-associated macrophages), CD34 (microvessel density, MVD) and VEGF expression, immunohistochemistry, MMP-2 and MMP-9 activity, zymography. Statistical analysis was conducted using Pearson’s test, Kaplan–Meier survival analysis, log-rank test and Cox proportional hazards model. Results: Intratumoral hypoxia level has been signifi cantly correlated with VEGF expression, TAM number and total protease activity. The overall survival rate of patients with strong tumour hypoxia, high level of MVD, VEGF expression, TAM and MMP activity was signifi cantly lower than that of the patients without the mentioned tumour characteristics. Conclusions: The hypoxia-associated signalling that is activated in tumours promotes tumour progression through the recruitment of macrophages, remodelling of extracellular matrix and neoangiogenesis. uk_UA
dc.language.iso en uk_UA
dc.publisher Clinical Translational Oncology uk_UA
dc.subject Hypoxia-associated events uk_UA
dc.subject Gastric cancer uk_UA
dc.subject Prognostic markers uk_UA
dc.title Hypoxia, tumour-associated macrophages, microvessel density, VEGF and matrix metalloproteinases in human gastric cancer: interaction and impact on survival. uk_UA
dc.type Article uk_UA


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